Radiofármacos PET sintetizados mediante complejos de renio por vía acuosa

Researchers at the Australian Nuclear Science and Technology Organisation (ANSTO) have led the development of a new method for producing positron emission tomography (PET)radiotracers. The discovery utilizes the transition metal rhenium to promote fluorine-18 radiolabelling under aqueous, low temperature conditions. The method circumvents the need for dry conditions, and purification steps, which saves time and gives PET radiotracers in very high yields. Ver notica fuente en: itn

Artículo original:

Abstract: Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine- 18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal -mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.

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